Diversification of Heteroaryl‐Aryl Ether via Ligand‐Free, Copper‐Catalyzed O‐Arylation Under Microwave Heating,Bulletin of the Korean Chemical Society

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Diversification of Heteroaryl‐Aryl Ether via Ligand‐Free, Copper‐Catalyzed O‐Arylation Under Microwave Heating
Bulletin of the Korean Chemical Society ( IF 2.3 ) Pub Date : 2020-08-11 , DOI: 10.1002/bkcs.12075
Sung Min Choi ₁ , Jeong Seob Byeon ₁ , Eul Kgun Yum ₁

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Diverse O‐arylated pyrrolo[2,3‐d]pyrimidine and pyrrolo[2,3‐b]pyridine were obtained using relatively low amounts of Cu catalyst with ligand‐free conditions under microwave heating. The O‐arylation reaction could be applied to less oxidative heteroaryl‐chlorides. The microwave‐assisted Cu‐catalyzed O‐aryaltion would be useful for preparing potent bioactive compounds for drug discovery while reducing waste, time, and saving energy.

中文翻译：

微波加热下无铜铜催化O-芳基化作用使杂芳基-芳基醚多样化

在相对较低的无配位条件下，在微波加热条件下，使用相对少量的铜催化剂，可以得到不同的O-芳基化吡咯并[2,3- d ]嘧啶和吡咯并[2,3- b ]吡啶。所述Ô -arylation反应可以适用于更小的氧化杂芳基氯化物。微波辅助的Cu催化的O芳构化将有助于制备有效的生物活性化合物以用于药物发现，同时减少浪费，时间并节省能源。

更新日期：2020-08-11

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