The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression,Cell Proliferation

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The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-08-10 , DOI: 10.1111/cpr.12887
Chao Tu _{1,

2} , Kexin Yang ₃ , Lu Wan _{1,

2} , Jieyu He ₄ , Lin Qi _{1,

2} , Wanchun Wang _{1,

2} , Qiong Lu _{2,

5} , Zhihong Li _{1,

2}

Affiliation

LncRNAs play a pivotal role in the regulation of epigenetic modification, cell cycle, differentiation, proliferation, migration and other physiological activities. In particular, considerable studies have shown that the aberrant expression and dysregulation of lncRNAs are widely implicated in cancer initiation and progression by acting as tumour promoters or suppressors. Hippo signalling pathway has attracted researchers’ attention as one of the critical cancer‐related pathways in recent years. Increasing evidences have demonstrated that lncRNAs could interact with Hippo cascade and thereby contribute to acquisition of multiple malignant hallmarks, including proliferation, metastasis, relapse and resistance to anti‐cancer treatment. Specifically, Hippo signalling pathway is reported to modulate or be regulated by widespread lncRNAs. Intriguingly, certain lncRNAs could form a reciprocal feedback loop with Hippo signalling. More speculatively, lncRNAs related to Hippo pathway have been poised to become important putative biomarkers and therapeutic targets in human cancers. Herein, this review focuses on the crosstalk between lncRNAs and Hippo pathway in carcinogenesis, summarizes the comprehensive role of Hippo‐related lncRNAs in tumour progression and depicts their clinical diagnostic, prognostic or therapeutic potentials in tumours.

中文翻译：

lncRNAs与Hippo信号通路在癌症进展中的串扰

LncRNAs在表观遗传修饰、细胞周期、分化、增殖、迁移等生理活动的调控中发挥着举足轻重的作用。特别是，大量研究表明，lncRNA 的异常表达和失调通过充当肿瘤启动子或抑制子广泛参与癌症的发生和进展。Hippo信号通路作为近年来重要的癌症相关通路之一引起了研究人员的关注。越来越多的证据表明，lncRNAs 可以与 Hippo 级联相互作用，从而有助于获得多种恶性标志，包括增殖、转移、复发和抗癌治疗耐药性。具体而言，据报道 Hippo 信号通路调节或受广泛的 lncRNA 调控。耐人寻味的是，某些 lncRNA 可以与 Hippo 信号形成互惠反馈回路。更具推测性的是，与 Hippo 通路相关的 lncRNA 已准备好成为重要的假定生物标志物和人类癌症的治疗靶点。在此，本综述重点关注 lncRNA 与 Hippo 通路在致癌作用中的相互作用，总结了 Hippo 相关 lncRNA 在肿瘤进展中的综合作用，并描述了它们在肿瘤中的临床诊断、预后或治疗潜力。

更新日期：2020-08-10

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