Through the accumulation of adaptive mutations, HIV‐2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross‐species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4⁺ T‐cell decline as the virus was passaged in humanized mice.

中文翻译：

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人源化小鼠中 SIVsm 向 HIV-2 的进化。

通过适应性突变的积累，HIV-2起源于SIVsm。为了识别这些进化变化，一个人性化的小鼠模型概括了可能促成这种跨物种传播事件的过程。随着病毒在人源化小鼠中传代，出现了各种适应性突变，以及毒力增加和 CD4 ⁺ T 细胞下降。