Thiamphenicol (TP) pharmacokinetics were studied in Japanese quails (Coturnix japonica) following a single intravenous (IV) and oral (PO) administration at 30 mg/kg BW. Concentrations of TP were determined with HPLC and were analyzed by a noncompartmental method. After IV injection, elimination half‐life (t_1/2λz), total body clearance (Cl_tot) volume of distribution at steady state (V_dss), and mean residence time (MRT) of TP were 3.83 hr, 0.19 L/hr/kg, 0.84 L/kg, and 4.37 hr, respectively. After oral administration of TP, the peak plasma concentration (C_max) was 19.81 μg/ml and was obtained at 2.00 hr (t_max) postadministration. Elimination half‐life (t_1/2λz) and mean absorption time (MAT) were 4.01 hr and 1.56 hr, respectively. The systemic bioavailability following oral administration of TP was 78.10%. TP therapy with an oral dosage of 30 mg/kg BW is suggested for a beneficial clinical effect in quails.

中文翻译：

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单次静脉内和口服给药后，日本鹌鹑（Coturnix japonica）中甲砜霉素的药代动力学。

在以30 mg / kg体重的单次静脉内（IV）和口服（PO）给药后，在日本鹌鹑（Coturnix japonica）中研究了甲砜霉素（TP）的药代动力学。用HPLC测定TP的浓度，并用非房室法进行分析。静脉注射后，_TP的消除半衰期（t _{1 /2λz}），稳态下的总体清除率（Cl _tot）分布量（V _dss）和TP的平均停留时间（MRT）为3.83 hr，0.19 L / hr /kg、0.84 L / kg和4.37 hr。口服TP后，血浆峰值浓度（C _max）为19.81μg/ ml，在给药后2.00 hr（t _max）获得。消除半衰期（t_{1 /2λz}）和平均吸收时间（MAT）分别为4.01小时和1.56小时。TP口服后的全身生物利用度为78.10％。建议口服30 mg / kg BW的TP治疗对鹌鹑有有益的临床效果。