Natural products present neurotrophic properties in neurons of the limbic system in aging rodents.,SYNAPSE

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Natural products present neurotrophic properties in neurons of the limbic system in aging rodents.
SYNAPSE ( IF 1.6 ) Pub Date : 2020-08-11 , DOI: 10.1002/syn.22185
Gonzalo Flores ₁ , Gabriel Daniel Flores-Gómez ₂ , Alfonso Díaz ₃ , Julio César Penagos-Corzo ₄ , Tommaso Iannitti ₅ , Julio César Morales-Medina ₆

Affiliation

Aging is a complex process that can lead to neurodegeneration and, consequently, several pathologies, including dementia. Physiological aging leads to changes in several body organs, including those of the central nervous system (CNS). Morphological changes in the CNS and particularly the brain result in motor and cognitive deficits affecting learning and memory and the circadian cycle. Characterizing neural modifications is critical to designing new therapies to target aging and associated pathologies. In this review, we compared aging to the changes occurring within the brain and particularly the limbic system. Then, we focused on key natural compounds, apamin, cerebrolysin, Curcuma longa, resveratrol, and N‐PEP‐12, which have shown neurotrophic effects particularly in the limbic system. Finally, we drew our conclusions delineating future perspectives for the development of novel natural therapeutics to ameliorate aging‐related processes.

中文翻译：

天然产物在衰老啮齿动物的边缘系统神经元中具有神经营养特性。

衰老是一个复杂的过程，可导致神经退行性变，从而导致多种疾病，包括痴呆症。生理衰老会导致多种身体器官发生变化，包括中枢神经系统 (CNS) 的器官。中枢神经系统，尤其是大脑的形态学变化会导致运动和认知缺陷，影响学习和记忆以及昼夜节律周期。表征神经修饰对于设计针对衰老和相关病理的新疗法至关重要。在这篇综述中，我们将衰老与大脑，尤其是边缘系统中发生的变化进行了比较。然后，我们专注于关键的天然化合物，阿帕明、脑活素、姜黄、白藜芦醇和N-PEP-12，已显示出神经营养作用，特别是在边缘系统中。最后，我们得出了我们的结论，描绘了开发新型天然疗法以改善衰老相关过程的未来前景。

更新日期：2020-08-25

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