Time-of-flight mass spectrometry (TOFMS) is one of the simplest and most powerful approaches for mass spectrometry. Realization of the advantages inherent in TOFMS requires innovation in the theory and practice of the technique. Instrumental developments, in turn, create new capabilities that enable applications in chemical measurement. This review focuses on the recent advances in TOFMS instrumentation. New strategies for ion acceleration, multiplexed detection, miniaturized TOFMS instruments, approaches to extend the length of ion flight, and novel ion detection technologies are reviewed. Techniques that change the basic paradigm of TOFMS by measuring m/z based on ion flight distance are considered, as are applications at the frontiers of instrumental performance. © 2020 John Wiley & Sons Ltd. Mass Spec Rev

中文翻译：

---

飞行时间质谱仪仪器方法的最新进展

飞行时间质谱 (TOFMS) 是最简单、最强大的质谱方法之一。TOFMS 固有优势的实现需要技术理论和实践的创新。反过来，仪器的发展创造了新的能力，使化学测量的应用成为可能。本综述重点关注 TOFMS 仪器的最新进展。综述了离子加速、多重检测、小型化 TOFMS 仪器、延长离子飞行长度的方法以及新型离子检测技术的新策略。通过测量m / z改变 TOFMS 基本范式的技术考虑了基于离子飞行距离的应用，以及仪器性能前沿的应用。© 2020 John Wiley & Sons Ltd. 质谱修订版