Editan (Lasianthera africana) leaf‐inclusive diets modulate some neuronal enzyme activities and antioxidant status of cyclophosphamide‐treated Wistar rats,Journal of Food Biochemistry

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Editan (Lasianthera africana) leaf‐inclusive diets modulate some neuronal enzyme activities and antioxidant status of cyclophosphamide‐treated Wistar rats
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-08-11 , DOI: 10.1111/jfbc.13427
Esther Emem Nwanna ₁ , Sunday Idowu Oyeleye _{1,

2} , Ganiyu Oboh ₁

Affiliation

The effect of Editan (Lasianthera africana) leaf inclusive diet (ELD) on neuronal cholinesterases (ChE), ecto‐5'‐nucleotidase, and endogenous antioxidant indices [superoxide dismutase (SOD), catalase (CAT), glutathione (GSH)] in cyclophosphamide (CYP)‐administered albino rats were investigated. Thirty male albino Wistar rats were dissevered appropriately (n = 6). Group I—normal control rats (NC), II–untreated CYP‐administered rats, III‐CYP‐administered rats pre‐treated with donepezil (DON), group IV–CYP‐administered rats fed ELD, and V‐normal rats fed with ELD for 21 days. Results obtained revealed that CYP‐administered rats significantly (p < .05) had elevated activities of ChE, ecto‐5'‐nucleotidase and thiobarbituric acid reactive species (TBARS), and concomitantly decreased in the antioxidant indices. However, pre‐treatment with either DON or ELD reversed these effects, thereby eliciting a therapeutic effect which could be linked to the rich polyphenol and alkaloid constituents in the studied leaf, and could be responsible for the potential ethnopharmacological actions of the ELD in the management neurodegeneration.

中文翻译：

Editan（Lasianthera africana）含叶饮食调节环磷酰胺处理的Wistar大鼠的某些神经元酶活性和抗氧化状态

Editan（Lasianthera africana）叶包容性饮食（ELD）对神经元胆碱酯酶（ChE），ecto-5'-核苷酸酶和内源性抗氧化剂指数[超氧化物歧化酶（SOD），过氧化氢酶（CAT），谷胱甘肽（GSH）]的影响研究了使用环磷酰胺（CYP）的白化病大鼠。将30只雄性白化病Wistar大鼠适当地切开（n = 6）。I组-正常对照组（NC），II组未经CYP给药的大鼠，III组CYP给予多奈哌齐（DON）预处理的大鼠，IV组-CYP给药的ELD小鼠和V组给予CYP的正常大鼠ELD 21天。获得的结果表明，CYP给药的大鼠显着（p <.05）的ChE，ecto-5'-核苷酸酶和硫代巴比妥酸反应性物种（TBARS）的活性升高，并且抗氧化剂指数随之降低。但是，用DON或ELD预处理可以逆转这些作用，从而引起治疗作用，该作用可能与研究叶片中的丰富多酚和生物碱成分有关，并可能对ELD在处理中的潜在民族药理作用负责。神经变性。

更新日期：2020-08-11

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