Selenoimidazolium Salts as Supramolecular Reagents for Protein Alkylation.,ChemBioChem

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Selenoimidazolium Salts as Supramolecular Reagents for Protein Alkylation.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-08-11 , DOI: 10.1002/cbic.202000557
David Lim ₁ , Xiaojin Wen ₁ , Florian P Seebeck ₁

Affiliation

Smart leaving groups: Selenoimidazolium salts leverage supramolecular interactions for selective covalent modification of proteins. SAR studies show that interactions with the N‐benzyl side chains of the electrophile are important to recognize and activate the specific nucleophilic substrate. Selenoimidazoles′ modular structure and simple synthesis bode well for developing second‐generation supramolecular reagents that could alkylate specific residues in other proteins of interest.

中文翻译：

硒代咪唑鎓盐作为蛋白质烷基化的超分子试剂。

聪明的离去基团：硒代咪唑鎓盐利用超分子相互作用来选择性地对蛋白质进行共价修饰。SAR研究表明，与亲电试剂的N-苄基侧链相互作用对于识别和激活特定的亲核底物很重要。硒代咪唑的模块结构和简单的合成预示着第二代超分子试剂的开发，该试剂可以将其他目的蛋白质中的特定残基烷基化。

更新日期：2020-08-11

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