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Haemopoietic cell transplantation in patients living with HIV.
The Lancet HIV ( IF 16.1 ) Pub Date : 2020-08-10 , DOI: 10.1016/s2352-3018(20)30117-x
Richard F Ambinder 1 , Adam A Capoferri 2 , Christine M Durand 1
Affiliation  

Haemopoietic cell transplantation is established as a standard treatment approach for people living with HIV who have haematological malignancies with poor prognosis. Studies with autologous and allogeneic haemopoietic cell transplantation suggest that HIV status does not adversely affect outcomes, provided that there is adequate infection prophylaxis. Attention to possible drug–drug interactions is important. Allogeneic haemopoietic cell transplantation substantially reduces the long-term HIV reservoir when complete donor chimerism is established. When transplants from CCR5Δ32 homozygous donors are used, HIV cure is possible.



中文翻译:

HIV感染者的造血细胞移植。

造血细胞移植已成为治疗患有预后不良的血液系统恶性肿瘤的艾滋病毒感染者的标准治疗方法。自体和同种异体造血细胞移植的研究表明,只要有足够的感染预防措施,艾滋病毒状态不会对结果产生不利影响。注意可能的药物间相互作用很重要。当建立完全的供体嵌合状态时,同种异体造血细胞移植可显着减少艾滋病毒的长期储存。当使用来自CCR5 Δ32 纯合捐赠者的移植物时,艾滋病毒治愈是可能的。

更新日期:2020-08-10
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