The present work investigated the specific phenomena involved in the simultaneous scCO₂ impregnation of two compounds in polymers. For this purpose, poly(L- lactic acid) and linear low density polyethylene were impregnated with three different combinations of two compounds among aspirin, ketoprofen and carvone. The loadings were studied regarding the effect of the impregnation conditions ({60 °C; 9 MPa} and {80 °C; 30 MPa}), the polymer/compound and the scCO₂/compound interactions using DSC, SEM and FTIR and compared to the loadings obtained when a single compound was impregnated. Two synergistic effects were observed and accounted to the plasticizing and cryogenic effect of ketoprofen and carvone that facilitated the diffusion of aspirin and ketoprofen, respectively. Chain mobility and polymer/compound interaction are necessary to the synergy. The preliminary study of in vitro release showed faster ketoprofen and aspirin release from the PLLA double impregnation samples, as a result of their increased free volume.

本工作研究了聚合物中两种化合物同时scCO ₂浸渍的具体现象。为此，用阿司匹林，酮洛芬和香芹酮中的两种化合物的三种不同组合浸渍聚（L-乳酸）和线性低密度聚乙烯。研究了关于浸渍条件（{60°C； 9 MPa}和{80°C； 30 MPa}），聚合物/化合物和scCO ₂的影响的载荷使用DSC，SEM和FTIR分析化合物与化合物的相互作用，并将其与浸渍单一化合物时获得的载荷进行比较。观察到两种协同作用，并分别归因于酮洛芬和香芹酮的塑化和低温效应分别促进阿司匹林和酮洛芬的扩散。链的流动性和聚合物/化合物的相互作用是协同作用所必需的。体外释放的初步研究表明，由于其自​​由体积增加，酮洛芬和阿司匹林从PLLA双重浸渍样品中释放得更快。