Although T cells are considered as the central component in immune-mediated diseases, supportive evidence has demonstrated that B cells also contribute to the progression of these diseases. B cells are divided into various subsets according to their secreted cytokines. Different B cell subsets play diverse roles in immune-mediated dermatoses. Regulatory B cells (Bregs) are defined functionally by their ability to secrete IL-10, which has been revealed to contribute to immunological tolerance. Drugs that deplete B cells, such as rituximab, are now used for the treatment of several immune-mediated dermatoses. In this review, we present and discuss the current knowledge on the roles of B cells in several immune-mediate dermatoses including psoriasis, pemphigus, bullous pemphigoid, and dermatomyositis, atopic dermatitis.

尽管T细胞被认为是免疫介导疾病的主要成分，但支持性证据表明B细胞也有助于这些疾病的发展。B细胞根据其分泌的细胞因子分为不同的亚组。不同的B细胞亚群在免疫介导的皮肤病中起着不同的作用。调节性B细胞（Bregs）在功能上由其分泌IL-10的能力来定义，该能力已被证明有助于免疫耐受。消耗掉B细胞的药物（如利妥昔单抗）现在用于治疗几种免疫介导的皮肤病。在这篇综述中，我们介绍和讨论有关B细胞在几种免疫介导的皮肤病（包括牛皮癣，天疱疮，大疱性天疱疮和皮肌炎，特应性皮炎）中的作用的当前知识。