Bioactive glasses (BGs) are of great interest in fields of medical engineering owing to their biocompatibility, biodegradability and bioactivity. In addition, spray pyrolysis was demonstrated as a novel way to obtain BG particles with various compositions and dopants while controlling the particle morphologies. In the present study, BGs doped with Manganese (Mn), an ion that has been shown to be osteoconductive, were prepared by spray pyrolysis method. Characterizations of crystallographic structure, particle morphology and chemical compositions were carried out by X-ray diffractometer, scanning electron microscope, transmission electron microscope and energy dispersive spectroscopy, respectively. Furthermore, evaluation of in vitro bioactivity was performed regarding the formation of hydroxyapatite layer while the colony count method was used to examine the antibacterial activity against E. coli bacteria. Finally, the results show that both bioactivity and antibacterial activity were enhanced with dopant of Mn and related mechanisms were discussed.

生物活性玻璃（BG）由于其生物相容性，生物降解性和生物活性而在医学工程领域引起了极大的兴趣。另外，喷雾热解被证明是获得具有各种组成和掺杂剂的BG颗粒同时控制颗粒形态的新颖方法。在本研究中，通过喷雾热解法制备了掺杂有锰（Mn）的BG，锰已被证明具有骨传导性。分别通过X射线衍射仪，扫描电子显微镜，透射电子显微镜和能量色散光谱对晶体结构，颗粒形态和化学组成进行表征。此外，大肠杆菌。最终，结果表明，锰掺杂提高了生物活性和抗菌活性，并探讨了相关机理。