The objective of this study was to assess the impact of microbiological test reports that provide specific written recommendations on the appropriate management of Staphylococcus aureus bacteremia (SAB). We performed a retrospective analysis of laboratory and clinical data of all SAB patients treated at one German University hospital, 2012–2015. Among 467 included patients, methicillin-resistant S. aureus (MRSA) accounted for 15.2% of all SAB cases. All-cause in-hospital mortality was 25.2%, and was significantly elevated in individuals aged >55 years, in MRSA bacteremia and if the source of infection remained unidentified. Focus identification was achieved in 71.1%, with the most prevalent foci being catheter-associated bloodstream infection (23.1%), soft tissue infection (15.4%), osteomyelitis (5.1%) and endocarditis (4.9%). Standardized written recommendations on microbiological test reports led to a significant increase of transesophageal echocardiography, additional imaging studies for focus identification and more frequent follow-up blood cultures, but no significant effect on mortality was observed.

这项研究的目的是评估微生物检测报告的影响，这些报告对适当管理金黄色葡萄球菌菌血症（SAB）提供了具体的书面建议。我们对2012-2015年在德国一家大学医院接受治疗的所有SAB患者的实验室和临床数据进行了回顾性分析。在467名患者中，耐甲氧西林的金黄色葡萄球菌（MRSA）占所有SAB病例的15.2％。全因住院死亡率为25.2％，如果年龄大于55岁，MRSA菌血症以及感染源仍不确定，则显着升高。在71.1％的人群中获得了病灶识别，最常见的病灶是与导管相关的血流感染（23.1％），软组织感染（15.4％），骨髓炎（5.1％）和心内膜炎（4.9％）。关于微生物学检验报告的标准化书面建议导致了经食道超声心动图检查的显着增加，用于焦点识别的其他影像学研究以及更频繁的随访血培养，但未观察到对死亡率的显着影响。