Goats are important food animals and are disseminated globally because of their high adaptability to varying environmental conditions and feeding regimes that provide them with a comparative advantage. Productivity is impacted by infectious diseases; this then contributes to societal poverty, food insecurity, and international trade restrictions. Since γδ T cells have been shown to have vital roles in immune responses in other mammals we reviewed the literature regarding what is known about their functions, distribution in tissues and organs and their responses to a variety of infections in goats. It has been shown that caprine γδ T cells produce interferon-γ and IL-17, are found in a variety of lymphoid and nonlymphoid tissues and constitute a significant population of blood mononuclear cells. Their representation in tissues and their functional responses may be altered concomitant with infection. This review summarizes caprine γδ T cell responses to Brucella melitensis, Fasciola hepatica, Mycobacterium avium paratuberculosis, caprine arthritis encephalitis virus (CAEV), and Schistosoma bovis in infected or vaccinated goats. Caprine γδ T cells have also been evaluated in goats infected with M. caprae, Ehrilichia ruminantium, Haemonchus contortus and peste des petits ruminants (PPR) virus but found to have an unknown or limited response or role in either protective immunity or immunopathogenesis in those cases.

山羊是重要的食用动物，因其对不同环境条件和喂养方式的高度适应性而在全球范围内传播，从而为它们提供了比较优势。生产力受到传染病的影响；这会导致社会贫困、粮食不安全和国际贸易限制。由于 γδ T 细胞已被证明在其他哺乳动物的免疫反应中具有重要作用，我们回顾了有关其功能、组织和器官分布及其对山羊各种感染的反应的文献。已经表明，山羊 γδ T 细胞产生干扰素-γ 和 IL-17，存在于各种淋巴和非淋巴组织中，并构成大量血液单核细胞。它们在组织中的表现及其功能反应可能会随着感染而改变。本综述总结了山羊 γδ T 细胞对布鲁氏菌、肝片吸虫、副结核分枝杆菌、山羊关节炎脑炎病毒 (CAEV) 和感染或接种过疫苗的山羊中的牛血吸虫。山羊 γδ T 细胞也在感染山羊分枝杆菌、反刍埃里希氏菌、扭曲血矛线虫和小反刍兽疫 (PPR) 病毒的山羊中进行了评估，但发现在这些情况下，它们在保护性免疫或免疫发病机制中具有未知或有限的反应或作用.