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N-terminal pro B-type natriuretic peptide (NT-proBNP): a possible surrogate of biological age in the elderly people.
GeroScience ( IF 5.3 ) Pub Date : 2020-08-11 , DOI: 10.1007/s11357-020-00249-2
Antonio Muscari 1 , Giampaolo Bianchi 1 , Paola Forti 1 , Donatella Magalotti 2 , Paolo Pandolfi 3 , Marco Zoli 1 ,
Affiliation  

NT-proB-type natriuretic peptide (NT-proBNP) increases with age and is associated with all-cause mortality. With this study, we assessed its possible utilization as a marker of biological age in comparison with other variables. The study included 1079 non-institutionalized elderly subjects (mean age 72.8 ± 5.5 years, 561 women). Baseline measurements were performed of serum NT-proBNP and of some laboratory variables previously utilized to estimate biological age (creatinine, albumin, C-reactive protein, cholesterol, blood glucose, leukocytes, lymphocytes, hemoglobin, mean cell volume). During 7 years of follow-up, 114 all-cause deaths occurred. The logarithm of NT-proBNP was the most age-related parameter (r = 0.35, P < 0.0001). Its relationship with mortality, according to Cox regression and ROC curve (AUC = 0.707, 95% CI 0.654–0.759), was stronger than that of all other variables, including age. In multivariate analysis, only NT-proBNP and age remained independently associated with mortality. The regression lines between age and NT-proBNP (pg/ml) allowed a separate estimation of biological age (“proBNPage”) for men (= [log(NT-proBNP) + 1.2068]/0.0827) and for women (= [log(NT-proBNP) − 1.5258]/0.0478). The hazard ratio of all-cause mortality for the fifth quintile of proBNP age (≥ 85 years) compared with the first quintile (< 61 years) was 7.9 (95% CI 3.6–17.5). Similarly, the difference between pro-BNPage and chronological age was associated with a hazard ratio of 3.5 in the fifth quintile (95% CI 1.9–6.4) and was associated with disease count (P for trend = 0.0002). In conclusion, NT-proBNP was the best indicator of biological age, which can be estimated by simple formulas and might be used for prognostic purposes or as a surrogate end point in epidemiological and intervention studies.



中文翻译:

N 末端 B 型利钠肽原 (NT-proBNP):老年人生物年龄的可能替代指标。

NT-proB 型利钠肽 (NT-proBNP) 随着年龄的增长而增加,并与全因死亡率相关。通过这项研究,我们与其他变量相比,评估了其作为生物年龄标记的可能性。该研究包括 1079 名非住院老年受试者(平均年龄 72.8 ± 5.5 岁,其中 561 名女性)。对血清 NT-proBNP 和一些先前用于估计生物年龄的实验室变量(肌酐、白蛋白、C 反应蛋白、胆固醇、血糖、白细胞、淋巴细胞、血红蛋白、平均细胞体积)进行基线测量。在 7 年的随访期间,发生了 114 例全因死亡。NT-proBNP 的对数是与年龄最相关的参数(r  = 0.35,P  < 0.0001)。根据 Cox 回归和 ROC 曲线(AUC = 0.707,95% CI 0.654–0.759),其与死亡率的关系强于所有其他变量(包括年龄)。在多变量分析中,只有 NT-proBNP 和年龄仍然与死亡率独立相关。年龄和 NT-proBNP (pg/ml) 之间的回归线允许单独估计男性 (= [log(NT-proBNP) + 1.2068]/0.0827) 和女性 (= [log (NT-BNP 前体)−1.5258]/0.0478)。proBNP 年龄的第五个五分位(≥ 85 岁)与第一个五分位(< 61 岁)相比,全因死亡率的风险比为 7.9(95% CI 3.6-17.5)。同样,pro-BNPage 和实际年龄之间的差异与第五个五分位数中 3.5 的风险比相关(95% CI 1.9-6.4),并且与疾病计数相关(趋势P = 0.0002)总之,NT-proBNP 是生物年龄的最佳指标,可以通过简单的公式进行估计,并可用于预后目的或作为流行病学和干预研究的替代终点。

更新日期:2020-08-11
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