Abstract

Thermosensitive nanoparticles were synthesized by acylation of branched polyethyleneimine with isobutyroyl chloride and cross-linking by 1,6-hexamethylene diisocyanate. It was found that colloidal aqueous solutions of these particles reversibly lose solubility around physiological temperature. The influence of the composition of the nanoparticle on their hydrodynamic parameters, as well as on the phase transition temperatures in aqueous solutions was evaluated.

中文翻译：

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基于聚乙烯亚胺作为生物医学应用有望材料的热敏纳米粒子

摘要

通过将支化的聚乙烯亚胺与异丁酰氯酰化并通过1,6-六亚甲基二异氰酸酯交联来合成热敏纳米粒子。发现这些颗粒的胶体水溶液在生理温度附近可逆地失去溶解性。评估了纳米颗粒的组成对其流体力学参数以及水溶液中相变温度的影响。