The mechanical properties of human blood are incompletely understood and constitute an underdeveloped area of study, prohibiting mechanically-based clinical diagnoses. Using the unique transient rheological signature of a blood sample, there is a possibility that blood rheology measurements could be used as a method of diagnosis and/or differentiation. We present here the response of blood to large amplitude oscillatory shear (LAOS) and reversing flow ramps, where hysteresis curves are typically formed. Results of these tests are visualized by blood “mechanical contours” that have the advantage of depicting the evolving mechanical properties of the material over a wide range of flow conditions. The sequence of physical process (SPP) method is applied to elucidate the changes undergone by the blood during the transient flows. This method is advantageous because it allows for the analysis of a wide range of transient flow protocols, rather than being restricted to strictly sinusoidal functions. We show a novel approach to the analysis of the large amplitude oscillatory shear tests in the form of mechanical contour maps. We also show the Cole-Cole plots and analysis for LAOS measurements using the same blood measurements. This allows a complete picture of the mechanical properties of the blood and a possible basis for comparison to pathological mechanical markers moving forward.

中文翻译：

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非线性血液流变学的小规模研究显示快速瞬态转变

人类血液的机械特性尚不完全清楚，构成了一个欠发达的研究领域，禁止基于机械的临床诊断。使用血液样本的独特瞬态流变学特征，血液流变学测量有可能用作诊断和/或区分的方法。我们在这里展示了血液对大振幅振荡剪切 (LAOS) 和反向流动斜坡的响应，其中通常形成滞后曲线。这些测试的结果通过血液“机械轮廓”进行可视化，其优点是可以描述材料在各种流动条件下不断变化的机械性能。应用物理过程序列（SPP）方法来阐明血液在瞬态流动过程中所经历的变化。这种方法是有利的，因为它允许分析范围广泛的瞬态流协议，而不是仅限于严格的正弦函数。我们展示了一种以机械等高线图的形式分析大振幅振荡剪切测试的新方法。我们还使用相同的血液测量显示了 LAOS 测量的 Cole-Cole 图和分析。这允许全面了解血液的机械特性，并为与病理机械标记进行比较提供可能的基础。我们还使用相同的血液测量显示了 LAOS 测量的 Cole-Cole 图和分析。这允许全面了解血液的机械特性，并为与病理机械标记进行比较提供可能的基础。我们还使用相同的血液测量显示了 LAOS 测量的 Cole-Cole 图和分析。这允许全面了解血液的机械特性，并为与病理机械标记进行比较提供可能的基础。