The work is focused on physiological role of the hormone kisspeptin produced by neurons of the hypothalamus anterior zone, which is a key regulator of reproduction processes. Role of the hormone in transmission of information on metabolic activity and induction of the secretion of gonadotropin-releasing hormone (GnRH) by the hypothalamus that determines gestation processes involving fertilization, placentation, fetal development, and child birth is considered. The literature data on molecular mechanisms and effects of kisspeptin on reproductive system including puberty initiation are summarized and analyzed. In addition, attention is paid to hormone-mediated changes in the cardiovascular system in pregnant women. For the first time, the review examines the effect of kisspeptin on functional activity of immune system cells presenting molecular mechanisms of the hormone signal transduction on the level of lymphoid cells that lead to the immune tolerance induction. In conclusion, a conceptual model is presented that determines the role of kisspeptin as an integrator of reproductive and immune functions during pregnancy.

中文翻译：

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Kisspeptin 在调节生殖和免疫反应中的作用

这项工作的重点是由下丘脑前区神经元产生的激素 Kisspeptin 的生理作用，这是生殖过程的关键调节剂。考虑了激素在代谢活动信息的传递和下丘脑分泌促性腺激素释放激素 (GnRH) 中的作用，下丘脑决定了涉及受精、胎盘、胎儿发育和分娩的妊娠过程。总结分析了kisspeptin对包括青春期开始在内的生殖系统的分子机制和影响的文献资料。此外，还关注孕妇心血管系统中激素介导的变化。首次，该综述检查了kisspeptin对免疫系统细胞功能活性的影响，展示了激素信号转导对淋巴细胞水平的分子机制，导致免疫耐受诱导。总之，提出了一个概念模型，该模型确定了 Kisspeptin 在怀孕期间作为生殖和免疫功能整合者的作用。