The dynamic behavior of the tumor suppressor p53 as an important signal in response to various stresses can influence cellular fate decisions. Programmed cell death 5 (PDCD5) and wild type p53-induced phosphatase 1 (Wip1) regulate p53 dynamics as its activator and inhibitor, respectively. In the present study, we add Wip1 to p53-Mdm2 (Murine double minute 2) module with PDCD5 and focus on p53 dynamics depending on PDCD5 and ataxia telangiectasia mutated (ATM) degradation rate regulated by Wip1. The bifurcation results reveal that p53 dynamics varies with these two parameters. p53 exhibits monostability and bistabiltiy for smaller and larger PDCD5 level while p53 shows oscillation or coexistence of oscillation and steady states in a narrow parameter range. These dynamics are further explored by time series and potential landscapes. Our results may be useful for regulating cell fate upon DNA damage.

中文翻译：

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取决于 PDCD5 水平和 ATM 降解率的 p53 动力学的分叉和潜在景观

肿瘤抑制因子 p53 作为响应各种压力的重要信号的动态行为可以影响细胞命运决定。程序性细胞死亡 5 (PDCD5) 和野生型 p53 诱导的磷酸酶 1 (Wip1) 分别作为其激活剂和抑制剂调节 p53 动力学。在本研究中，我们将 Wip1 添加到带有 PDCD5 的 p53-Mdm2（小鼠双分钟 2）模块中，并专注于 p53 动力学取决于 PDCD5 和由 Wip1 调节的共济失调毛细血管扩张症（ATM）降解率。分叉结果表明 p53 动力学随这两个参数而变化。p53 对于越来越小的 PDCD5 水平表现出单稳态和双稳态，而 p53 在狭窄的参数范围内表现出振荡或振荡与稳态共存。这些动态通过时间序列和潜在景观进一步探索。