An extracellular matrix (ECM) mimicking architecture was introduced with gelatin glycosaminoglycans like hyaluronic acid and chondroitin sulfate and a triterpenoid using asiatic acid, possessing biodegradable and biocompatible properties that mark the functionality for the treatment of second-degree burn wounds. In the present work, a foam-based scaffold was fabricated and sterilized with gamma radiation at a 2.5 Mrad dose. The scaffolds were further characterized for morphology, swelling, degradation behaviour, release of bioactive components, ATR-FTIR, mechanical, thermal properties and compared with control. In vitro cytocompatibility of the developed scaffold was studied with L929 mouse fibroblast cells and human mesenchymal stem cells based on deoxyribonucleic acid and lactate dehydrogenase assay. Additionally, the developed scaffold was evaluated for its biocompatibility on the Wistar rat to assess any toxicity induced to the animal based on blood biochemistry and h...

中文翻译：

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基于明胶/透明质酸/硫酸软骨素/积雪草酸的生物聚合物支架的制备和评估，用于治疗二度烧伤 - Wistar 大鼠模型研究。

细胞外基质 (ECM) 模拟结构引入了明胶糖胺聚糖，如透明质酸和硫酸软骨素，以及使用积雪草酸的三萜，具有可生物降解和生物相容性的特性，标志着治疗二度烧伤的功能。在目前的工作中，制造了一个基于泡沫的支架，并用 2.5 Mrad 剂量的伽马辐射进行消毒。进一步表征支架的形态、溶胀、降解行为、生物活性成分的释放、ATR-FTIR、机械、热性能，并与对照进行比较。基于脱氧核糖核酸和乳酸脱氢酶测定，用 L929 小鼠成纤维细胞和人间充质干细胞研究了所开发支架的体外细胞相容性。此外，