Cobalt-Catalyzed Markovnikov Selective Sequential Hydrogenation/Hydrohydrazidation of Aliphatic Terminal Alkynes,Journal of the American Chemical Society

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Cobalt-Catalyzed Markovnikov Selective Sequential Hydrogenation/Hydrohydrazidation of Aliphatic Terminal Alkynes
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-08-09 , DOI: 10.1021/jacs.0c07258
Jieping Chen ₁ , Xuzhong Shen ₁ , Zhan Lu ₁

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Here, we reported for the first time a mechanistically distinctive cobalt-catalyzed Markovnikov-type sequential semihydrogenation/hydrohydrazidation of aliphatic terminal alkynes in one pot. A cobalt hydride species was employed as two roles for both a unique metal-catalyzed Markovnikov-type insertion of the aliphatic terminal alkynes and then metal-catalyzed hydrogen atom transfer of alkenes. This operationally simple protocol exhibits excellent functional group tolerance and step economy. The hydrazone products could be easily transferred to various valuable amine derivatives.

中文翻译：

钴催化的马尔科夫尼科夫选择性连续氢化/氢肼化脂肪族末端炔

在这里，我们首次报道了一种机械上独特的钴催化马尔科夫尼科夫型连续半氢化/氢酰肼的脂肪族末端炔烃。钴氢化物被用作脂肪族末端炔烃的独特金属催化马尔可夫尼科夫型插入和烯烃的金属催化氢原子转移的两种作用。这种操作简单的协议表现出出色的功能组耐受性和步骤经济性。腙产物可以很容易地转移到各种有价值的胺衍生物中。

更新日期：2020-08-09

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