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Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19.
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2020-08-10 , DOI: 10.1021/acsmedchemlett.0c00409
Tianxiong Mi 1 , Kevin Burgess 1
Affiliation  

Four of five different monoclonal antibodies (mAbs) that have been crystallized in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S) have remarkably similar primary and secondary loop structures at the heavy chain complementarity-determining regions (HCDR) 1 and 2. All these reports give a structural basis for the deceptively difficult problem of accurate peptidomimetic loop mimic design.

中文翻译:

中和COVID-19的某些mAb中CDR之间的惊人相似性。

与SARS-CoV-2穗突蛋白(S)的受体结合域(RBD)形成复杂结晶的五种不同的单克隆抗体(mAb)中的四种在重链互补性测定中具有非常相似的一级和二级环结构区域(HCDR)1和2。所有这些报告为准确拟肽环模拟设计的看似困难的问题提供了结构基础。
更新日期:2020-09-10
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