Women with polycystic ovary syndrome (PCOS) are characterized by endocrine disorders accompanied by a decline in oocyte quality. In this study, we generated a PCOS mice model by hypodermic injection of dehydroepiandrosterone, and metformin was used as a positive control drug to study the effect of pachymic acid (PA) on endocrine and oocyte quality in PCOS mice. Compared with the model group, the mice treated with PA showed the following changes (slower weight gain, improved abnormal metabolism; increased development potential of GV oocytes, reduced number of abnormal MII oocytes, and damaged embryos; lower expression of ovarian-related genes in ovarian tissue and pro-inflammatory cytokines in adipose tissue). All these aspects show similar effects on metformin. Most notably, PA is superior to metformin in improving inflammation of adipose tissue and mitochondrial abnormalities. It is suggested that PA has the similar effect with metformin, which can improve the endocrine environment and oocyte quality of PCOS mice. These findings suggest that PA has the similar effect with metformin, which can improve the endocrine environment and oocyte quality of PCOS mice.

中文翻译：

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Pachymic acid 通过改善 PCOS 小鼠的卵巢微环境来保护卵母细胞。

患有多囊卵巢综合征 (PCOS) 的女性的特征是内分泌失调并伴有卵母细胞质量下降。在本研究中，我们通过皮下注射脱氢表雄酮建立了 PCOS 小鼠模型，并以二甲双胍作为阳性对照药物，研究了肉豆蔻酸 (PA) 对 PCOS 小鼠内分泌和卵母细胞质量的影响。与模型组相比，PA处理的小鼠出现以下变化（增重减慢，代谢异常改善；GV卵母细胞发育潜力增加，异常MII卵母细胞数量减少，胚胎受损；卵巢相关基因表达降低）卵巢组织和脂肪组织中的促炎细胞因子）。所有这些方面都显示出对二甲双胍的类似影响。最为显着地，PA在改善脂肪组织炎症和线粒体异常方面优于二甲双胍。提示PA与二甲双胍作用相似，可改善PCOS小鼠的内分泌环境和卵母细胞质量。这些发现表明PA与二甲双胍具有相似的作用，可以改善PCOS小鼠的内分泌环境和卵母细胞质量。