Locally injected lipid nanoparticles that deliver RNA to elicit danger signals and simultaneously contain RNA that encodes a membrane-anchored version of the cytokine IL-12 can induce immunogenic cell death in tumors. This multipronged platform induces anticancer immune responses to the injected lesion as well as to distant tumors and hence produces an abscopal effect.

中文翻译：

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用于免疫治疗的假病毒

局部注射的脂质纳米颗粒可传递 RNA 以引发危险信号，同时含有编码细胞因子 IL-12 的膜锚定版本的 RNA，可诱导肿瘤中的免疫原性细胞死亡。这种多管齐下的平台诱导对注射病变以及远处肿瘤的抗癌免疫反应，从而产生远隔效应。