Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a member of transcriptional coactivator of the peroxisome proliferator-activated receptor. It is involved in lipid metabolism, energy metabolism, adipocyte differentiation and regulation of mitochondrial biogenesis. Therefore, the genetic variation of PPARGC1A gene will be of great value. The purposes of this study were to detect novel InDels within the PPARGC1A gene and analyze the effects of genetic polymorphisms on growth traits. We detected a novel 17 bp insertion polymorphism within the eleventh intron of the sheep PPARGC1A gene. Experimental results revealed that the InDel (insertion/deletion) genotypes distribution of the seven breeds of sheep was significant differences, of which three genotypes were detected. After correlation analysis, there were many significant phenotypic differences between the body size traits of the three genotypes. Interestingly, the dominant genotype was different in body weight both in STHS sheep and HS sheep. In summary, the 17 bp insertion polymorphism within the PPARGC1A gene had a great influence on the growth traits of sheep, which may provide a potential theoretical basis for marker-assisted selection in sheep genetic breeding.

过氧化物酶体增殖物激活受体 γ 辅激活因子 1-α ( PPARGC1A ) 是过氧化物酶体增殖物激活受体转录辅激活因子的成员。它参与脂质代谢、能量代谢、脂肪细胞分化和线粒体生物发生的调节。因此，PPARGC1A基因的遗传变异将具有重要价值。本研究的目的是检测PPARGC1A基因中的新 InDels 并分析遗传多态性对生长性状的影响。我们在绵羊PPARGC1A第 11 个内含子中检测到一个新的 17 bp 插入多态性基因。实验结果表明，7个品种绵羊的InDel（插入/缺失）基因型分布存在显着差异，其中检测到3个基因型。经相关性分析，三个基因型的体型性状之间存在许多显着的表型差异。有趣的是，在 STHS 羊和 HS 羊中，显性基因型的体重不同。综上所述，PPARGC1A基因内的17 bp插入多态性对绵羊的生长性状有较大影响，可为绵羊遗传育种中的标记辅助选择提供潜在的理论依据。