Left ventricular assist devices provide circulatory support to patients with end-stage heart failure. The standard operating conditions of the pump imply limitations on the rotation speed of the rotor. In this work we validate a model for three pumps (Sputnik 1, Sputnik 2, Sputnik D) using a mock circulation facility and known data for the pump HeartMate II. We combine this model with a 1D model of haemodynamics in the aorta and a lumped model of the left heart with valves dynamics. The model without pump is validated with known data in normal conditions. Simulations of left ventricular dilated cardiomyopathy show that none of the pumps are capable of reproducing the normal stroke volume in their operating ranges while complying with all criteria of physiologically feasible operation. We also observe that the paediatric pump Sputnik D can operate in the conditions of adult circulation with the same efficiency as the adult LVADs.

中文翻译：

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通过血液循环集成模型分析左心室辅助设备的操作模式

左心室辅助设备为患有终末期心力衰竭的患者提供循环支持。泵的标准运行条件意味着对转子转速的限制。在这项工作中，我们使用模拟循环设施和已知的HeartMate II泵数据验证了三个泵（Sputnik 1，Sputnik 2，Sputnik D）的模型。我们将此模型与主动脉血流动力学的一维模型以及具有瓣膜动力学的左心集总模型结合起来。不带泵的模型在正常情况下使用已知数据进行验证。左心室扩张型心肌病的模拟显示，在符合生理可行操作的所有标准的前提下，没有一种泵能够在其操作范围内再现正常的搏动量。