Summary The last decade has led to major shifts in opinions on the use of hydroxyethyl starch (HES) solutions in fluid therapy, specifically in human patients with sepsis The majority of evidence documenting adverse effects of HES solutions on coagulation and renal health come from studies in people However, these findings have led to investigation into the safety of HES solutions in veterinary species While there are now studies investigating the effects of HES solutions on coagulation and renal health in dogs, cats and horses, information regarding long-term follow-up, clinical significance of these changes and use of these solutions in critically ill animals is still lacking The information presented here serves to review the physiology of oncotic pressure and the rationale behind colloid use, specifically HES solutions Additionally, the foundation of arguments against the use of HES and the available literature regarding HES use in animals will be summarised

中文翻译：

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重新审视羟乙基淀粉溶液在马体液治疗中的应用

总结 在过去的十年中，关于在液体治疗中使用羟乙基淀粉 (HES) 溶液的观点发生了重大转变，特别是在人类败血症患者中 记录 HES 溶液对凝血和肾脏健康不利影响的大多数证据来自于以下方面的研究：人们然而，这些发现导致了对兽用 HES 溶液安全性的调查 虽然现在有研究调查 HES 溶液对狗、猫和马的凝血和肾脏健康的影响，关于长期随访的信息，这些变化的临床意义和这些解决方案在危重动物中的使用仍然缺乏这里提供的信息用于审查渗透压的生理学和胶体使用背后的基本原理，特别是 HES 解决方案此外，将总结反对使用 HES 的论据和有关 HES 在动物中使用的现有文献