This paper presents the noninvasive determination of cardiac output by peripheral electrical bioimpedance. We validate our approach first with small animals and then with human. We established an experimental protocol that allowed us to perform the measurements of several cardiovascular parameters by two methods, echocardiography and bioimpedance. For the rats, we used a group of 19 Wistar rats. Peripheral bioimpedance allowed us to obtain the blood flow index at the level of the rat's tail without sacrificing it. The objective being the determination of the cardiac output, a correlation with the measurements of the cardiac output by ultrasound has been established. The correlation obtained ‘0.83’ can be considered satisfactory and comparable to those obtained in similar human studies. For humans, a group of 32 healthy women, (age 21.3 ± 1.5 years) has participated in this study. Peripheral bioimpedance allowed us to obtain the index of blood flow at the patient's left arm and echocardiography allowed us to obtain the cardiac output. Then, we established a linear correlation between the two methods. The strength of the correlation obtained is ‘0.89’ and can be considered very satisfactory. The mean percentage of error in estimating cardiac output by the proposed method is 5.6%. © 2020 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.

中文翻译：

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外周电生物阻抗测定心输出量

本文介绍了通过周围生物电阻抗无创确定心输出量。我们首先对小型动物进行验证，然后对人类进行验证。我们建立了一个实验方案，使我们可以通过两种方法（超声心动图和生物阻抗）来测量几个心血管参数。对于大鼠，我们使用了19只Wistar大鼠。周围生物阻抗使我们能够在不牺牲大鼠尾巴水平的情况下获得血流指数。目的是确定心输出量，已经建立了与通过超声测量心输出量的相关性。可以将获得的“ 0.83”相关性与在相似的人体研究中获得的相关性相比较令人满意。对于人类，一组32位健康的女性，（年龄21.3±1。5年）参加了这项研究。周围生物阻抗使我们能够获得患者左臂的血流指数，而超声心动图技术可使我们获得心输出量。然后，我们在两种方法之间建立了线性相关性。获得的相关强度为'0.89'，可以认为是非常令人满意的。通过提出的方法估算心输出量的平均误差百分比为5.6％。©2020日本电气工程师学会。由Wiley Periodicals LLC发布。89'，可以说是非常令人满意的。通过提出的方法估算心输出量的平均误差百分比为5.6％。©2020日本电气工程师学会。由Wiley Periodicals LLC发布。89'，可以说是非常令人满意的。通过提出的方法估算心输出量的平均误差百分比为5.6％。©2020日本电气工程师学会。由Wiley Periodicals LLC发布。