Multicomponent DNA Polymerization Motor Gels.,Small

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Multicomponent DNA Polymerization Motor Gels.
Small ( IF 13.0 ) Pub Date : 2020-08-09 , DOI: 10.1002/smll.202002946
Ruohong Shi ₁ , Joshua Fern ₁ , Weinan Xu ₁ , Sisi Jia ₁ , Qi Huang ₁ , Gayatri Pahapale ₁ , Rebecca Schulman _{1,

2,

3} , David H Gracias _{1,

3,

4}

Affiliation

Hydrogels with the ability to change shape in response to biochemical stimuli are important for biosensing, smart medicine, drug delivery, and soft robotics. Here, a family of multicomponent DNA polymerization motor gels with different polymer backbones is created, including acrylamide‐co‐bis‐acrylamide (Am‐BIS), poly(ethylene glycol) diacrylate (PEGDA), and gelatin‐methacryloyl (GelMA) that swell extensively in response to specific DNA sequences. A common mechanism, a polymerization motor that induces swelling is driven by a cascade of DNA hairpin insertions into hydrogel crosslinks. These multicomponent hydrogels can be photopatterned into distinct shapes, have a broad range of mechanical properties, including tunable shear moduli between 297 and 3888 Pa and enhanced biocompatibility. Human cells adhere to the GelMA‐DNA gels and remain viable during ≈70% volumetric swelling of the gel scaffold induced by DNA sequences. The results demonstrate the generality of sequential DNA hairpin insertion as a mechanism for inducing shape change in multicomponent hydrogels, suggesting widespread applicability of polymerization motor gels in biomaterials science and engineering.

中文翻译：

多组分DNA聚合汽车凝胶。

具有响应生化刺激而改变形状的能力的水凝胶对于生物传感，智能药物，药物输送和软机器人技术非常重要。这里，具有不同的聚合物主链的多组分DNA聚合马达凝胶的家族被创建，包括丙烯酰胺-共双丙烯酰胺（Am-BIS），聚（乙二醇）二丙烯酸酯（PEGDA）和明胶-甲基丙烯酰基（GelMA），可对特定的DNA序列产生广泛的反应。常见的机制是诱导溶胀的聚合电动机是由将DNA发夹插入水凝胶交联中的级联驱动的。这些多组分水凝胶可以被光图案化为不同的形状，具有广泛的机械性能，包括在297和3888 Pa之间可调的剪切模量和增强的生物相容性。人类细胞粘附在GelMA-DNA凝胶上，并在DNA序列诱导的凝胶支架体积约70％溶胀期间保持活力。结果表明，顺序插入DNA发夹结构可作为诱导多组分水凝胶形状变化的机制，

更新日期：2020-09-18

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