当前位置: X-MOL 学术Pest Manag. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cytochrome P450-mediated herbicide metabolism in plants: current understanding and prospects.
Pest Management Science ( IF 3.8 ) Pub Date : 2020-08-09 , DOI: 10.1002/ps.6040
Niña Gracel Dimaano 1 , Satoshi Iwakami 2
Affiliation  

Cytochrome P450s (P450s) have been at the center of herbicide metabolism research as a result of their ability to endow selectivity in crops and resistance in weeds. In the last 20 years, ≈30 P450s from diverse plant species have been revealed to possess herbicide‐metabolizing function, some of which were demonstrated to play a key role in plant herbicide sensitivity. Recent research even demonstrated that some P450s from crops and weeds metabolize numerous herbicides from various chemical backbones, which highlights the importance of P450s in the current agricultural systems. However, due to the enormous number of plant P450s and the complexity of their function, expression and regulation, it remains a challenge to fully explore the potential of P450‐mediated herbicide metabolism in crop improvement and herbicide resistance mitigation. Differences in the substrate specificity of each herbicide‐metabolizing P450 are now evident. Comparisons of the substrate specificity and protein structures of P450s will be beneficial for the discovery of selective herbicides and may lead to the development of crops with higher herbicide tolerance by transgenics or genome‐editing technologies. Furthermore, the knowledge will help design sound management strategies for weed resistance including the prediction of cross‐resistance patterns. Overcoming the ambiguity of P450 function in plant xenobiotic pathways will unlock the full potential of this enzyme family in advancing global agriculture and food security. © 2020 Society of Chemical Industry

中文翻译:

细胞色素P450介导的植物除草剂代谢:当前的认识和前景。

由于细胞色素P450(P450)具有赋予作物选择性和杂草抗性的能力,因此一直是除草剂代谢研究的中心。在过去的20年中,已发现约30种来自不同植物物种的P450具有除草剂代谢功能,其中一些已证明在植物除草剂敏感性中起关键作用。最近的研究甚至表明,一些农作物和杂草中的P450会代谢来自各种化学骨架的多种除草剂,这突出了P450在当前农业系统中的重要性。然而,由于植物P450的数量众多,其功能,表达和调控的复杂性,充分探索P450介导的除草剂代谢在作物改良和减轻除草剂抗性方面的潜力仍然是一个挑战。现在已经清楚了每种代谢除草剂的P450在底物特异性上的差异。P450s底物特异性和蛋白质结构的比较将有助于发现选择性除草剂,并可能通过转基因或基因组编辑技术开发出具有更高除草剂耐受性的农作物。此外,这些知识将有助于设计合理的杂草抗性管理策略,包括交叉抗性模式的预测。克服植物异种途径中P450功能的歧义将释放该酶家族在促进全球农业和粮食安全方面的全部潜力。©2020化学工业协会 P450s底物特异性和蛋白质结构的比较将有助于发现选择性除草剂,并可能通过转基因或基因组编辑技术开发出具有更高除草剂耐受性的农作物。此外,这些知识将有助于设计合理的杂草抗性管理策略,包括交叉抗性模式的预测。克服植物异种途径中P450功能的歧义,将释放该酶家族在促进全球农业和粮食安全方面的全部潜力。©2020化学工业协会 P450s底物特异性和蛋白质结构的比较将有助于发现选择性除草剂,并可能通过转基因或基因组编辑技术开发出具有更高除草剂耐受性的农作物。此外,这些知识将有助于设计针对杂草抗性的合理管理策略,包括预测交叉抗性模式。克服植物异种途径中P450功能的歧义将释放该酶家族在促进全球农业和粮食安全方面的全部潜力。©2020化学工业协会 这些知识将有助于设计合理的杂草抗性管理策略,包括预测交叉抗性模式。克服植物异种途径中P450功能的歧义将释放该酶家族在促进全球农业和粮食安全方面的全部潜力。©2020化学工业协会 这些知识将有助于设计合理的杂草抗性管理策略,包括预测交叉抗性模式。克服植物异种途径中P450功能的歧义将释放该酶家族在促进全球农业和粮食安全中的全部潜力。©2020化学工业协会
更新日期:2020-08-09
down
wechat
bug