Neuroanatomy of transgender persons in a Non-Western population and improving reliability in clinical neuroimaging.,Journal of Neuroscience Research

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Neuroanatomy of transgender persons in a Non-Western population and improving reliability in clinical neuroimaging.
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2020-08-10 , DOI: 10.1002/jnr.24702
Behzad Sorouri Khorashad _{1,

2} , Behnaz Khazai ₃ , Ali Talaei ₂ , Freya Acar ₄ , Anna R Hudson ₅ , Nahid Borji ₆ , Hedieh Saberi ₇ , Behzad Aminzadeh ₆ , Sven C Mueller _{5,

8}

Affiliation

Although the neuroanatomy of transgender persons is slowly being charted, findings are presently discrepant. Moreover, the major body of work has focused on Western populations. One important factor is the issue of power and low signal‐to‐noise (SNR) ratio in neuroimaging studies of rare study populations including endocrine or neurological patient groups. The present study focused on the structural neuroanatomy of a Non‐Western (Iranian) sample of 40 transgender men (TM), 40 transgender women (TW), 30 cisgender men (CM), and 30 cisgender women (CW), while assessing whether the reliability of findings across structural anatomical measures including gray matter volume (GMV), cortical surface area (CSA), and cortical thickness (CTh) could be increased by using two back‐to‐back within‐session structural MRI scans. Overall, findings in transgender persons were more consistent with sex assigned at birth in GMV and CSA, while no group differences emerged for CTh. Repeated measures analysis also indicated that having a second scan increased SNR in all regions of interest, most notably bilateral frontal poles, pre‐ and postcentral gyri and putamina. The results suggest that a simple time and cost‐effective measure to improve SNR in rare clinical populations with low prevalence rates is a second anatomical scan when structural MRI is of interest.

中文翻译：

非西方人群中跨性别者的神经解剖学和提高临床神经影像学的可靠性。

尽管正在缓慢绘制跨性别者的神经解剖学图表，但研究结果目前存在差异。此外，主要工作集中在西方人口上。一个重要的因素是在罕见研究人群（包括内分泌或神经病患者群体）的神经影像学研究中的功率和低信噪比 (SNR) 问题。本研究侧重于 40 名跨性别男性 (TM)、40 名跨性别女性 (TW)、30 名顺性别男性 (CM) 和 30 名顺性别女性 (CW) 的非西方（伊朗）样本的结构神经解剖学，同时评估是否通过使用两个背靠背的会话内结构 MRI 扫描，可以增加结构解剖测量结果的可靠性，包括灰质体积 (GMV)、皮质表面积 (CSA) 和皮质厚度 (CTh)。总体，在 GMV 和 CSA 中，跨性别者的发现与出生时分配的性别更一致，而 CTh 没有出现组间差异。重复测量分析还表明，第二次扫描增加了所有感兴趣区域的信噪比，最显着的是双侧额极、中央前和后回和壳核。结果表明，当结构 MRI 感兴趣时，在罕见的临床人群中提高 SNR 的简单时间和成本效益措施是第二次解剖扫描。

更新日期：2020-10-04

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