The amelioration of ulcerative colitis induced by Dinitrobenzenesulfonic acid with Radix Hedysari.,Journal of Food Biochemistry

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The amelioration of ulcerative colitis induced by Dinitrobenzenesulfonic acid with Radix Hedysari.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-08-09 , DOI: 10.1111/jfbc.13421
Gengen Shi ₁ , Donghan Wang ₁ , Zhiyuan Xue ₁ , Xianglin Zhou ₁ , Yaoyao Fang ₁ , Shilan Feng ₁ , Lianggong Zhao ₂

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Ulcerative colitis (UC) is a chronic inflammatory disease with an unknown precise etiology. This study proves that Radix Hedysari (RH) ameliorates UC. Four RH extracts were used to ameliorate UC induced by 2,4‐Dinitrobenzenesulfonic acid by 7 days intervention in agreement to preliminary studies. Compared to treatment with RH extracts, the RH ethanol extract (EE) was found to be more effective in ameliorating UC. With EE, the DAI were significantly decreased. Macroscopic and histopathological assessments suggest that the colon mucosa was repaired, the organizational structure of the colon had been rebuilt. The levels of MPO, TNF‐α, IL‐1β, and MDA were significantly decreased (p < .01), the levels of T‐SOD and CAT were significantly increased (p < .01). Moreover, the compounds in EE were analyzed by HPLC. The results show that EE can ameliorate UC, and its anti‐inflammatory capability probably plays an important role. RH can act as a functional food and ameliorate UC.

中文翻译：

红芪对二硝基苯磺酸所致溃疡性结肠炎的改善作用。

溃疡性结肠炎（UC）是一种慢性炎症性疾病，其确切病因尚不清楚。这项研究证明红芪 (RH) 可改善 UC。使用四种 RH 提取物通过 7 天干预来改善 2,4-二硝基苯磺酸诱导的 UC，这与初步研究一致。与 RH 提取物治疗相比，RH 乙醇提取物 (EE) 在改善 UC 方面更有效。使用 EE 后，DAI 显着降低。宏观和组织病理学评估表明结肠粘膜得到修复，结肠的组织结构得到重建。 MPO、TNF-α、IL-1β 和 MDA 水平显着降低 ( p < .01)，T-SOD 和 CAT 水平显着升高 ( p < .01)。此外，通过 HPLC 分析了 EE 中的化合物。结果表明，EE可以改善UC，其抗炎能力可能发挥重要作用。 RH 可作为功能性食品并改善 UC。

更新日期：2020-10-11

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