A house‐cleaning enzyme: That the essential, cellular cofactor (S_s,S_c)‐S‐adenosylmethionine (SAM) can spontaneously racemize to the inactive (R_s,S_c)‐SAM remains underappreciated. We show that a protein containing a domain of unknown function 62 (DUF62) from the marine bacterium S. tropica acts as a stereoselective (R_s,S_c)‐SAM hydrolase, potentially representing a novel mechanism to maintain SAM homochirality.

中文翻译：

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含有未知功能 DUF62 的保守结构域的酶可作为立体选择性 (Rs ,Sc )-S-腺苷甲硫氨酸水解酶。

一种清洁房屋的酶：必需的细胞辅助因子 ( S _s ,S _c ) -S-腺苷甲硫氨酸 (SAM) 可以自发消旋为无活性的 ( R _s ,S _c )-SAM 仍然未被充分认识。我们表明，一种来自海洋细菌S.tropica的含有未知功能域 62 (DUF62) 的蛋白质可作为立体选择性 ( R _s , Sc ) _-SAM水解酶，可能代表一种维持 SAM 同手性的新机制。