Cyclic 1‐Azadienes in the Organocatalytic Inverse‐Electron‐Demand Aza‐Diels‐Alder Cycloadditions,Asian Journal of Organic Chemistry

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Cyclic 1‐Azadienes in the Organocatalytic Inverse‐Electron‐Demand Aza‐Diels‐Alder Cycloadditions
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-08-09 , DOI: 10.1002/ajoc.202000332
Anna Skrzyńska ₁ , Sebastian Frankowski ₁ , Łukasz Albrecht ₁

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The inverse‐electron‐demand hetero‐Diels‐Alder (IEDHDA) reaction constitutes a useful and highly reliable method for the construction of various heterocycles. In the manuscript, a recent progress in the organocatalytic IEDHDA cycloaddition using cyclic 1‐azadienes as hetero‐dienes has been summarized and discussed. Since 2010 many interesting, new reactions involving these substrates have been identified and developed. They are based on various organocatalytic activation modes providing access to valuable nitrogen‐heterocycles. Excellent stereochemical reliability of asymmetric organocatalysis combined with the importance of the structural motifs obtained as a result of the cycloaddition makes these strategies highly relevant for the contemporary organic synthesis.

中文翻译：

有机催化逆电子需求的氮杂-Diels-Alder环加成中的环1-氮杂二烯

逆电子需求杂狄尔斯-阿尔德（IEDHDA）反应是构建各种杂环的一种有用且高度可靠的方法。在手稿中，总结并讨论了使用环1氮杂二烯作为杂二烯的有机催化IEDHDA环加成反应的最新进展。自2010年以来，已经发现并开发了涉及这些底物的许多有趣的新反应。它们基于各种有机催化活化模式，可提供有价值的氮杂环。不对称有机催化的出色立体化学可靠性，以及由于环加成反应而获得的结构基序的重要性，使得这些策略与当代有机合成高度相关。

更新日期：2020-08-09

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