In 2011, Argentina launched a government-funded national Human papillomavirus (HPV) immunization program incorporating a bivalent HPV vaccine, with a 0–1–6-month schedule, for girls 11 years of age, born after January 2000. Monitoring the changes of HPV infection prevalence among young women has been proposed as an endpoint for early assessment of HPV vaccination programs. However, the data on HPV prevalence at young ages are very limited. The aim of this work was to determine the prevalence of HPV infection and type-specific distribution in sexually active 15–17-year-old non-vaccinated girls. Cervical samples from 1073 adolescents were collected for HPV detection and genotyping using the BSGP5+/GP6+PCR-reverse line blot (RLB) assay. Out of 957 specimens analyzed, 56.3% were positive for any HPV type; 42.2% harbored at least one high-risk HPV (HR-HPV) type and 30.8% low-risk HPV (LR-HPV) types. Multiple and single infections were identified in 36.3% and 20.0% of the samples respectively. The 6 most common HR-HPV types were HPV16 (11.1%), HPV52 (10.8%), HPV56 (8.3%), HPV51 (7.4%), HPV58 (7.3%) and HPV31 (7.1%). The prevalence of HR-HPV-16/18 was 15.2%. In conclusion, results confirm that HPV (particularly HR-types) are very common among sexually active adolescents, and prevalence rises quickly after their sexual debut. Our HPV type-specific prevalence baseline may be used to monitor post-vaccinal longitudinal changes in Argentina.

2011年，阿根廷推出了由政府资助的国家人乳头瘤病毒2000 年 1 月之后出生的 11 岁女孩，包含双价 HPV 疫苗的 (HPV) 免疫计划，计划为 0-1-6 个月。 监测年轻女性中 HPV 感染率的变化已被提议作为终点用于早期评估 HPV 疫苗接种计划。然而，关于年轻时期 HPV 流行率的数据非常有限。这项工作的目的是确定性活跃的 15-17 岁未接种疫苗的女孩中 HPV 感染的流行率和类型特异性分布。收集了 1073 名青少年的宫颈样本，使用 BSGP5+/GP6+PCR-反向线印迹 (RLB) 检测进行 HPV 检测和基因分型。在分析的 957 份样本中，56.3% 的任何 HPV 类型均呈阳性；42.2% 至少含有一种高危 HPV (HR-HPV) 类型，30.8% 具有低危 HPV (LR-HPV) 类型。分别在 36.3% 和 20.0% 的样本中发现了多重感染和单一感染。6 种最常见的 HR-HPV 类型是 HPV16 (11.1%)、HPV52 (10.8%)、HPV56 (8.3%)、HPV51 (7.4%)、HPV58 (7.3%) 和 HPV31 (7.1%)。HR-HPV-16/18 的患病率为 15.2%。总之，结果证实 HPV（尤其是 HR 型）在性活跃的青少年中非常普遍，并且在首次性行为后流行率迅速上升。我们的 HPV 类型特异性患病率基线可用于监测阿根廷疫苗接种后的纵向变化。结果证实 HPV（特别是 HR 型）在性活跃的青少年中非常普遍，并且在首次性行为后流行率迅速上升。我们的 HPV 类型特异性患病率基线可用于监测阿根廷疫苗接种后的纵向变化。结果证实 HPV（特别是 HR 型）在性活跃的青少年中非常普遍，并且在首次性行为后流行率迅速上升。我们的 HPV 类型特异性患病率基线可用于监测阿根廷疫苗接种后的纵向变化。