The extracellular matrix (ECM) plays a major role in cancer progression through its increased deposition and alignment. In this issue of Developmental Cell, Fattet et al. reveal a pathway in which ECM stiffness promotes EPHA2/LYN complex activation, leading to TWIST1 nuclear localization and triggering EMT in breast cancer.

中文翻译：

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将矩阵刚度与EMT和癌症入侵联系起来。

细胞外基质（ECM）通过增加沉积和排列在癌症进展中起主要作用。在本期《发育细胞》中，Fattet等人。揭示了ECM刚度促进EPHA2 / LYN复合物激活，导致TWIST1核定位并触发乳腺癌EMT的途径。