OBJECTIVE Type-1 diabetes (T1D) is a disruptive metabolic disease that has an impact on neurodevelopment through its effects on the structure and function of the brain. One of the cognitive domains affected by T1D is sustained attention. The aim of this study was to analyze this process in children with T1D and compare their results to those of healthy controls. METHODS Seventeen T1D children attending regular primary school and a similar group of healthy children matched by gender, age, handedness, and educational level were evaluated while identifying happy faces in a Go-NoGo task presented visually with simultaneous electrophysiological recording. RESULTS Behavioral performance in the two groups was similar but, the T1D children showed greater prefrontal and frontoparietal spectral power in the theta and alpha bands, compared to controls. Distinct patterns of theta lateralization between groups were also observed, with a negative correlation between frontal power magnitudes in delta and theta and glycated hemoglobin levels. CONCLUSIONS These results seem to reflect the early deleterious effects of T1D on neurodevelopment, which affects mainly attention allocation processes and the neurofunctional substrates that underlie them. SIGNIFICANCE This phenomenon emphasizes the need for studies on neural-specific targets in which T1D affects neurodevelopment.

中文翻译：

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对 1 型糖尿病学童的持续关注。定量脑电图研究

目标 1 型糖尿病 (T1D) 是一种破坏性代谢疾病，通过影响大脑的结构和功能对神经发育产生影响。受 T1D 影响的认知领域之一是持续关注。本研究的目的是分析 T1D 儿童的这一过程，并将他们的结果与健康对照组的结果进行比较。方法 对 17 名就读普通小学的 T1D 儿童和一组类似的健康儿童进行了评估，这些儿童在性别、年龄、惯用手和教育水平方面进行了匹配，同时在 Go-NoGo 任务中识别快乐的面孔，同时通过同步电生理记录进行视觉呈现。结果 两组的行为表现相似，但与对照组相比，T1D 儿童在 theta 和 alpha 波段显示出更大的前额叶和额顶叶光谱功率。还观察到组之间不同的 theta 侧化模式，delta 和 theta 的额叶功率大小与糖化血红蛋白水平呈负相关。结论 这些结果似乎反映了 T1D 对神经发育的早期有害影响，主要影响注意力分配过程和作为其基础的神经功能底物。意义 这一现象强调了对 T1D 影响神经发育的神经特异性靶点进行研究的必要性。这主要影响注意力分配过程及其背后的神经功能底物。意义 这一现象强调了对 T1D 影响神经发育的神经特异性靶点进行研究的必要性。这主要影响注意力分配过程及其背后的神经功能底物。意义 这一现象强调了对 T1D 影响神经发育的神经特异性靶点进行研究的必要性。