当前位置: X-MOL 学术Exp. Brain Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Behavioral-genetic associations in the Human Connectome Project.
Experimental Brain Research ( IF 1.7 ) Pub Date : 2020-08-10 , DOI: 10.1007/s00221-020-05893-w
Peka Christova 1, 2 , Jasmine Joseph 1, 3 , Apostolos P Georgopoulos 1, 2, 4, 5
Affiliation  

The Human Connectome Project (HCP) provides a rich dataset of quantitative and domain-specific behavioral measures from twins and extensive family structures. This makes the dataset a unique and a valuable resource to investigate heritability and determine individual differences. Using a set of measures of behavioral domains (motor, emotion, personality, sensory, and cognition), we estimated the intraclass correlations (ICCs) and heritability of 56 behavioral measures for 4 genetically identified groups of participants: monozygotic (MZ) twins, dizygotic (DZ) twins, non-twin siblings (SB), and unrelated individuals (NR). The ICCs range varied among behavioral domains but systematically so among the four genetic groups. We found the same rank order of ICCs, from the highest values for MZ twins, statistically significantly smaller for the DZ twins and sibling group (compared to MZ), and close to zero for NR. The mean heritability values of the five behavioral domains were: cognition h2 = 0.405, emotion h2 = 0.316, motor h2 = 0.138, personality h2 = 0.444, and sensory h2 = 0.193. These domains share overlapping brain networks. The heritability of motor domain was significantly smaller than cognitive, personality, and emotion domains. These findings provide new insight into the effect of genetics on the various diverse behavioral measures.



中文翻译:

人类Connectome项目中的行为遗传关联。

人类连接基因组计划(HCP)提供了一个丰富的数据集,其中包含来自双胞胎和广泛家庭结构的定量和特定领域的行为指标。这使数据集成为调查遗传力和确定个体差异的独特且宝贵的资源。使用一组行为域(运动,情绪,性格,感觉和认知)的量度,我们估计了4种经过遗传识别的参与者组的56种行为量度的类内相关性(ICC)和遗传力:单卵(MZ)双胞胎,双卵(DZ)双胞胎,非双胞胎兄弟姐妹(SB)和无关的个人(NR)。ICC的范围在行为域之间有所不同,但在四个基因组之间系统地变化。我们从MZ双胞胎的最高值中发现了相同的ICC等级顺序,DZ双胞胎和同胞兄弟姐妹组的统计数据明显较小(与MZ相比),而NR则接近零。五个行为域的平均遗传力值为:认知h 2  = 0.405,情感h 2  = 0.316,运动h 2  = 0.138,性格h 2  = 0.444,感觉h 2  = 0.193。这些域共享重叠的大脑网络。运动域的遗传力显着小于认知,人格和情感域。这些发现提供了对遗传学对各种不同行为措施的影响的新见解。

更新日期:2020-08-10
down
wechat
bug