Dense tumor stroma can severely restrict the ability of therapeutic drugs to penetrate into the deep tissue of solid tumors, and thereby inhibit the therapeutic efficacy of cancer nanomedicines. To address this issue, we have developed a synergistic optical strategy for deep-tumor penetration, in which thermophilic enzymes that can deplete tumor stroma are loaded and delivered by mesoporous polydopamine-coated plasmonic nanorods (termed AuNR@mPDA). Due to its high efficiency of photothermal conversion (56.5%) in the second near-infrared (NIR-II) window, AuNR@mPDA can activate thermophilic enzymes to enable on-demand enzymatic depletion of the tumor stroma, thus greatly promoting deep-tumor penetration of AuNR@mPDA. The excellent ability of NIR-II light to penetrate tissue is also crucial to facilitate photothermal therapy in the deep tissue of tumors to enhance in vivo therapeutic efficacy. The current NIR-II optical strategy for the synergistic enzymatic depletion of tumor stroma and photothermal therapy in deep tissue opens a promising avenue for effective treatment of solid tumors.

中文翻译：

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在第二个近红外窗口中增强深肿瘤穿透和治疗的协同光学策略

致密的肿瘤基质可严重限制治疗药物渗透到实体瘤深层组织的能力，从而抑制癌症纳米药物的治疗功效。为了解决这个问题，我们开发了一种用于深层肿瘤穿透的协同光学策略，其中可以消融肿瘤基质的嗜热酶由介孔的聚多巴胺涂层等离子纳米棒（称为AuNR @ mPDA）加载和传递。由于在第二个近红外（NIR-II）窗口中具有很高的光热转换效率（56.5％），AuNR @ mPDA可以激活嗜热酶，从而按需酶消减肿瘤基质，从而极大地促进了深层肿瘤AuNR @ mPDA的渗透。体内治疗功效。当前的NIR-II光学策略用于协同酶促消耗肿瘤基质和深层组织中的光热疗法，为有效治疗实体瘤开辟了有希望的途径。