Connexins and pannexins are two kinds of transmembrane proteins, which play important physiological roles. Connexins form hemichannels and channels, mainly contributing to the formation of gap junctions. Pannexins are newly discovered gap junction proteins and their structures consist of intracellular N-termini, intracellular C termini, an intracellular loop, two extracellular loops, and four transmembrane regions [1]. Because the extracellular domains of pannexins contain glycosylated asparagine residues, pannexins cannot form intercellular channels [2], but in the plasma membrane they can form large pores that can be permeated by ions and other molecules such as ATP [3].

中文翻译：

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新型线粒体相关膜蛋白Pannexin-2可能成为治疗和预防神经系统疾病的新策略。

连接蛋白和泛新蛋白是两种跨膜蛋白，起着重要的生理作用。连接蛋白形成半通道和通道，主要有助于间隙连接的形成。Pannexins是新发现的间隙连接蛋白，其结构由细胞内N末端，细胞内C末端，细胞内环，两个细胞外环和四个跨膜区域组成[1]。因为pannexins的胞外域包含糖基化的天冬酰胺残基，所以pannexins无法形成细胞间通道[2]，但是在质膜上它们可以形成大的孔，这些孔可以被离子和其他分子（例如ATP）渗透[3]。