Abstract

By using a mixed-ligand method, two new Co(II)-based coordination polymers with the chemical formula of [Co(L)(2,2′-bipy)]_n (1, 2,2′-bipy = 4,4′-bipyridine) and [Co(L)(phen)]_n (2, phen = 1,10-phenanthroline) have been successfully synthesized by the solvothermal reaction of 1,4-bis(3-carboxylbenzyl)piperazine acid (H₂L) and different N-donor co-ligands with the metal salt Co(NO₃)·6H₂O. Furthermore, a grinding method was used to prepare the nanoparticles of the two coordination polymers with average size distribution around 350 and 200 nm. The protective activity against the Alzheimer's disease (AD) was assessed and the specific mechanism was discussed at the same time. First of all, the ELISA detection assay was conducted and the content of the Amyloid (Aβ) in the brain was determined after compounds 1 and 2 treatment. In addition to this, the Annexin V-FITC/PI staining was performed and the protective activity of compounds 1 and 2 on neurons was evaluated.

抽象的

通过使用混合配体方法中，两个新的Co（II），用[CO（L）（2,2'-联吡啶）]的化学式为基础的配位聚合物_Ñ（1，2,2'-联吡啶= 4，通过1,4-双（3-羧基苄基）哌嗪酸（H的溶剂热反应）成功合成了4'-联吡啶）和[Co（L）（phen）] _n（2，phen = 1,10-菲咯啉）₂ L）以及不同的N-给体与金属盐Co（NO ₃）·6H _2的共配体O.此外，使用研磨方法来制备两种配位聚合物的纳米颗粒，其平均尺寸分​​布在350和200nm左右。评估了针对阿尔茨海默氏病（AD）的保护活性，并同时讨论了其具体机制。首先，进行了ELISA检测测定，并在化合物1和2处理后确定了大脑中淀粉样蛋白（Aβ）的含量。除此之外，进行膜联蛋白V-FITC / PI染色，并评估化合物1和2对神经元的保护活性。