Abstract This work reports on the characteristic of a 3D polymer gel dosimeter with poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic F-127) gel matrix. The dosimeter (acronym: VIP3-Pluronic F-127) comprises 4% (w/w) N-vinylpyrrolidone (NVP), 4% (w/w) N,N′-methylenebisacrylamide (MBA), 4% (w/w) tert-butanol, 10 mM tetrakis (hydroxymethyl)phosphonium chloride (THPC) and 25% (w/w) Pluronic F-127. A medical ionizing radiation source was used for irradiation of VIP3-Pluronic F-127 and the dosimeter was measured with a nuclear magnetic resonance (NMR, 0.47 T) relaxometer. The mean dose sensitivity of VIP3-Pluronic F-127 amounted to 0.1873 ± 0.0091 Gy−1 s−1, the intercept was equal to 1.3614 ± 0.0511 s−1, the linear dose response was in the range of 1–20 Gy, the dynamic dose range was of 1–50 Gy and the threshold dose was of ~1 Gy. The manufacturing process of VIP3-Pluronic F-127 was repeatable and the dosimeter was stable for at least 8 days after irradiation (no measurements for longer period were performed). It was also found that the dose response of VIP3-Pluronic F-127 is independent of the radiation dose rate and energy, and type of radiation (photons and electrons). The results obtained indicate that VIP3-Pluronic F-127 is promising as a polymer gel dosimeter for use in radiotherapy dosimetry.

中文翻译：

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具有 pluronic F-127 凝胶基质的新型含 N-乙烯基吡咯烷酮聚合物凝胶剂量计的表征

摘要 本工作报告了具有聚（环氧乙烷）-嵌段-聚（环氧丙烷）-嵌段-聚（环氧乙烷）（Pluronic F-127）凝胶基质的 3D 聚合物凝胶剂量计的特性。剂量计（缩写：VIP3-Pluronic F-127）包含 4% (w/w) N-乙烯基吡咯烷酮 (NVP)、4% (w/w) N,N'-亚甲基双丙烯酰胺 (MBA)、4% (w/w) ) 叔丁醇、10 mM 四（羟甲基）氯化鏻 (THPC) 和 25% (w/w) Pluronic F-127。使用医用电离辐射源照射 VIP3-Pluronic F-127，并使用核磁共振 (NMR, 0.47 T) 弛豫计测量剂量计。VIP3-Pluronic F-127 的平均剂量敏感性为 0.1873 ± 0.0091 Gy-1 s-1，截距等于 1.3614 ± 0.0511 s-1，线性剂量反应在 1-20 Gy 范围内，动态剂量范围为 1-50 Gy，阈值剂量为 ~1 Gy。VIP3-Pluronic F-127 的制造过程是可重复的，剂量计在辐照后至少稳定 8 天（没有进行更长时间的测量）。还发现 VIP3-Pluronic F-127 的剂量响应与辐射剂量率和能量以及辐射类型（光子和电子）无关。获得的结果表明，VIP3-Pluronic F-127 有望作为聚合物凝胶剂量计用于放射治疗剂量测定。还发现 VIP3-Pluronic F-127 的剂量响应与辐射剂量率和能量以及辐射类型（光子和电子）无关。获得的结果表明，VIP3-Pluronic F-127 有望作为聚合物凝胶剂量计用于放射治疗剂量测定。还发现 VIP3-Pluronic F-127 的剂量响应与辐射剂量率和能量以及辐射类型（光子和电子）无关。获得的结果表明，VIP3-Pluronic F-127 有望作为聚合物凝胶剂量计用于放射治疗剂量测定。