Analysis of plasma protein biomarkers in childhood onset multiple sclerosis,Journal of Neuroimmunology

当前位置： X-MOL 学术 › J. Neuroimmunol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Analysis of plasma protein biomarkers in childhood onset multiple sclerosis
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.jneuroim.2020.577359
Ismail Solmaz ₁ , Engin Kocak ₂ , Ozan Kaplan ₂ , Mustafa Celebier ₂ , Banu Anlar ₁

Affiliation

Abstract Multiple sclerosis (MS) manifesting before age 18 years is defined as pediatric MS (pMS). We analysed plasma proteins in pMS by an untargeted proteomic approach. Patients with pMS (Group pMS, n = 33), patients with demyelinating disease not meeting pMS diagnostic criteria (unclassified demyelinating disease, Group U, n = 4) and age-matched healthy subjects (Group C, n = 40) were included. Plasma proteomic analysis was performed using Q-TOF LC/MS. Proteins having fold change >1.2 and found to be statistically different (p

中文翻译：

儿童多发性硬化症血浆蛋白生物标志物分析

摘要 18 岁之前出现的多发性硬化症 (MS) 被定义为小儿 MS (pMS)。我们通过非靶向蛋白质组学方法分析了 pMS 中的血浆蛋白。包括 pMS 患者（pMS 组，n = 33）、不符合 pMS 诊断标准的脱髓鞘疾病患者（未分类的脱髓鞘疾病，U 组，n = 4）和年龄匹配的健康受试者（C 组，n = 40）。使用 Q-TOF LC/MS 进行血浆蛋白质组学分析。倍数变化 >1.2 且发现具有统计学差异的蛋白质 (p

更新日期：2020-11-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11