We present a unique case of metastatic cholangiocarcinoma with concurrent abdominal cestodiasis in an African green monkey (Chlorocebus pygerythrus) that presented with respiratory insufficiency and abdominal discomfort. There were multiple white–grey masses in the liver and colonic serosa alongside intra-abdominal parasitic cysts. Histopathologically, the liver masses were composed of poorly-differentiated epithelial cells that formed densely cellular solid areas and trabeculae. The neoplastic cells were strongly immunopositive for CK7 but negative for Hep-Par1 antigen, which confirmed a diagnosis of cholangiocarcinoma. Interestingly, there was strong and diffuse neoexpression in the tumour of the cell cycle regulator 14-3-3σ, which is not constitutively expressed in normal liver. There was aberrantly strong expression of E-cadherin, a key cell–cell adhesion protein, in neoplastic cells with evidence of cytoplasmic internalization. This is the first immunohistochemical analysis of 14-3-3σ and E-cadherin in a liver neoplasm in an animal species and the use of these markers requires further investigation in animal liver neoplasms.

我们在非洲绿猴（Chlorocebus pygerythrus）中并发腹部cestodiasis的转移性胆管癌的独特案例）表现为呼吸功能不全和腹部不适。肝脏和结肠浆膜中有多个白灰色块，并伴有腹腔内寄生性囊肿。在组织病理学上，肝脏肿块由分化较差的上皮细胞组成，形成了密集的细胞实性区域和小梁。肿瘤细胞对CK7具有强免疫阳性，但对Hep-Par1抗原呈阴性，这证实了胆管癌的诊断。有趣的是，在细胞周期调节剂14-3-3σ的肿瘤中有强烈而弥漫的新表达，而在正常肝脏中没有组成性表达。E-钙黏着蛋白（一种关键的细胞间粘附蛋白）在肿瘤细胞中异常强烈地表达，并有胞质内在化的迹象。