Immune cells, including macrophages and monocytes, remodel their metabolism and have specific nutritional needs when dealing with microbial pathogens. While we are just beginning to understand immunometabolism in fungal infections, emerging themes include recognition of fungal cell surface molecule driving metabolic remodelling to increase glycolysis, the critical role of glycolysis in the production of antifungal cytokines and fungicidal effector molecules, and the need for maintaining host glucose homeostasis to defeat fungal infections. A crosstalk between host and pathogen metabolic pathways determines the fate of immune cells and fungi when they interact. Thus, immunometabolic interactions offer potential for innovation in antifungal treatments in the future. For this to become a reality, we must decipher the mechanisms by which diverse fungal pathogens activate and manipulate immunometabolism.

在处理微生物病原体时，包括巨噬细胞和单核细胞在内的免疫细胞会重塑其代谢，并具有特定的营养需求。尽管我们才刚刚开始了解真菌感染中的免疫代谢，但新兴的主题包括对真菌细胞表面分子驱动代谢重塑以增加糖酵解的认识，糖酵解在抗真菌细胞因子和杀真菌效应分子生产中的关键作用以及维持宿主的需要葡萄糖体内平衡可以克服真菌感染。宿主与病原体代谢途径之间的串扰决定了免疫细胞和真菌相互作用时的命运。因此，免疫代谢相互作用为将来抗真菌治疗的创新提供了潜力。为了实现这一点，