Acrylamide (AA), which is mainly found in fried foods, causes neurotoxicity, genetic toxicity, carcinogenic effects, and DNA damage. This study confirms that a strain of lactic acid bacteria (Lactobacillus plantarum ATCC8014) could alleviate the toxicity of rats by inhibiting the AA-induced oxidative damage. Forty-eight adult male SD rats were randomly divided into eight groups: control group, AA group (40 mg/kg), three different doses (1 × 107 CFU/ml, 1 × 108 CFU/ml, 1 × 109 CFU/ml of Lactobacillus plantarum ATCC8014) of prevention groups and therapeutic groups, respectively. At the end of three-week experiment, AA treatment produced a significant reduction in the rate of weight gain along with the symptoms of hind limb splay and ataxia. Histological examinations revealed various degrees of injury in five tissues. Levels of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) in group AA rats were significantly decreased, but the level of lipid peroxidation (LPO) was significantly increased (p < 0.05). Both prevention and therapeutic groups with 1 × 109 CFU/ml of Lactobacillus plantarum ATCC8014 could effectively reduce the injury of AA to the body. However, reductions in both groups were not statistically significant.

中文翻译：

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的保护作用植物乳杆菌ATCC8014对大鼠丙烯酰胺诱导的氧化损伤

丙烯酰胺（AA）主要存在于油炸食品中，会引起神经毒性，遗传毒性，致癌作用和DNA损伤。这项研究证实，乳酸菌菌株（植物乳酸杆菌ATCC8014）可以通过抑制AA诱导的氧化损伤来减轻大鼠的毒性。48只成年雄性SD大鼠随机分为八组：对照组，AA组（40 mg / kg），三种不同剂量（1×107 CFU / ml，1×108 CFU / ml，1×109 CFU / ml）。预防组和治疗组分别接种植物乳杆菌（ATCC8014）。在为期三周的实验结束时，AA治疗使体重增加率显着降低，并伴有后肢裂和共济失调的症状。组织学检查发现五个组织受到不同程度的损伤。AA组大鼠的超氧化物歧化酶（SOD），过氧化氢酶（CAT）和谷胱甘肽（GSH）的水平显着降低，但脂质过氧化（LPO）的水平显着升高（p <0.05）。预防和治疗组均用1×109 CFU / ml的植物乳杆菌ATCC8014可以有效减少AA对身体的伤害。但是，两组的减少均无统计学意义。