Quality of life (QoL) includes complex interactions between objective and subjective factors. Through structural equation modeling, we analyzed people with Alzheimer disease (PwAD) and carers’ ratings to identify the factors associated with PwAD QoL. We included 264 PwAD and their carers. Model 1, carers’ ratings of PwAD QoL, showed a bidirectional association with worse depressive symptoms, lower functionality, and impairment on awareness being linked. These variables were associated with burden and all of them directly affecting carers’ ratings of PwAD QoL. Model 2, PwAD self-reported QoL, had the same bidirectional associations among the same variables with all of them influencing PwAD self-reported QoL. However, the interpretations of these similar associations should be different. The path analysis increased the understanding of the relationship between QoL and cognition, functionality, mood, awareness, and burden. Our findings bring together a number of consistent predictors and confirm their different effects in PwAD and carers’ point of view about QoL.

生活质量 (QoL) 包括客观和主观因素之间复杂的相互作用。通过结构方程模型，我们分析了阿尔茨海默病 (PwAD) 患者和护理人员的评级，以确定与 PwAD 生活质量相关的因素。我们包括了 264 PwAD 和他们的照顾者。模型 1，照顾者对 PwAD QoL 的评级，显示出与更严重的抑郁症状、较低的功能和意识障碍相关的双向关联。这些变量与负担相关，所有这些变量都直接影响照顾者对 PwAD QoL 的评级。模型 2，PwAD 自我报告的 QoL，在相同变量之间具有相同的双向关联，所有这些都影响 PwAD 自我报告的 QoL。但是，对于这些相似的联想，解释应该是不同的。路径分析增加了对 QoL 与认知、功能、情绪、意识和负担之间关系的理解。我们的研究结果汇集了许多一致的预测因素，并证实了它们在 PwAD 和照顾者关于 QoL 的观点中的不同影响。