OBJECTIVE Quantitative EEG (qEEG) is an established technique used as objective measure for evaluating the effect of antiseizure medications (ASMs) on EEG background activity and monitoring cognitive effects of ASMs. Perampanel (PER) has been associated with relatively more tolerable cognitive effects in patients with epilepsy. The primary aim of the present study was to verify the effect of PER as first add-on ASM on qEEG in child and adult patients affected by epilepsy. The secondary aim of this study was to verify the effectiveness of the drug as first add-on treatment in both child and adult patients with epilepsy. METHODS We collected data from 17 adults and 10 children treated with PER as first add-on treatment, who underwent qEEG analysis before starting PER and at 3-month follow-up under stable treatment. RESULTS PER resulted with significant effectiveness in reducing seizures in both children and adults. Considering qEEG analysis, we observed at follow-up the significant increase in beta1 and beta total bands both in children and adult patients. In particular, children showed the significant increase of beta band frequencies predominantly in the occipital regions, whereas adults showed a widespread increase of beta activity. Moreover, we documented in both child and adult patients the global reduction of delta bands activity. CONCLUSIONS This qEEG study documented the relative increase of cortical EEG fast activity in both children and adult patients affected by epilepsy and treated by PER. This result may suggest a potential less negative impact of PER on cognition in patients affected by epilepsy, other than demonstrating effectiveness of the drug when used as first add-on treatment in both children and adult patients.

中文翻译：

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Perampanel 增加受癫痫影响的儿童和成人患者的皮质 EEG 快速活动：一项定量 EEG 研究

目标定量 EEG (qEEG) 是一种既定技术，用作评估抗癫痫药物 (ASM) 对 EEG 背景活动的影响和监测 ASM 认知影响的客观测量方法。Perampanel (PER) 与癫痫患者相对更可耐受的认知影响有关。本研究的主要目的是验证 PER 作为第一个附加 ASM 对受癫痫影响的儿童和成人患者 qEEG 的影响。本研究的次要目的是验证该药物作为儿童和成人癫痫患者首次附加治疗的有效性。方法 我们收集了 17 名接受 PER 作为首次附加治疗的成人和 10 名儿童的数据，他们在开始 PER 之前和在稳定治疗下进行 3 个月的随访时进行了 qEEG 分析。结果 PER 在减少儿童和成人癫痫发作方面具有显着效果。考虑到 qEEG 分析，我们在随访中观察到儿童和成人患者的 beta1 和 beta 总带显着增加。特别是，儿童主要在枕骨区域表现出β波段频率的显着增加，而成年人则表现出β活动的广泛增加。此外，我们在儿童和成人患者中记录了 delta 带活动的全球减少。结论 该 qEEG 研究记录了受癫痫影响并接受 PER 治疗的儿童和成人患者皮质 EEG 快速活动的相对增加。这一结果可能表明 PER 对癫痫患者认知的潜在负面影响较小，