Background. Periodontitis is a kind of chronic infectious disease, affecting the health of billions of people. In recent years, a number of studies have shown that multiple immune gene polymorphisms are associated with the susceptibility to periodontitis, among which TLR-2 plays a critical role in periodontitis. But most of the studies reported TLR-2 gene polymorphism and susceptibility to periodontitis are not consistent. Therefore, we included all eligible studies in our study for further meta-analysis. Methods. We used electronic databases, including CNKI, PubMed, EMBASE, and Web of Science databases, and relevant research published through June, 2020. Selecting studies involved case-control trials. For all eligibility studies, odds ratios (ORs) and 95% confidence intervals (95% CI) are provided or can be calculated from the study data. The size of the combined effect was calculated using STATA 15.0. Results. Our meta-analysis included 14 articles representing 18 case-control studies with a total of 3873 cases and 3438 control subjects. Significant association was found between periodontitis and TLR-2 rs1898830 polymorphism under the allelic model (A allele vs. G allele: , , 95% CI: 1.039-1.406), recessive model (GG vs. GA+AA: , , 95% CI: 0.588-0.970), and codominant model (GG VS. AA: , , 95% CI: 0.501-0.925). In subgroup analysis, TLR-2 rs5743708 polymorphism was associated with periodontitis risk in Asians under an allelic model (G allele vs. A allele: , , 95% CI: 1.570-92.688), dominant model (GA+AA vs.GG: , , 95% CI: 0.010-0.620), and codominant model (GA VS. GG: , , 95% CI: 0.821-1.282). Conclusion. The TLR-2 rs1898830, rs5743708 polymorphism may be associated with susceptibility to periodontitis. In the future, genome-wide approaches and large-scale, multiethnic case-control trials are still needed.

中文翻译：

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TLR-2 基因多态性与牙周炎风险的关联：荟萃分析。

背景。牙周炎是一种慢性传染病，影响着数十亿人的健康。近年来，多项研究表明多种免疫基因多态性与牙周炎的易感性有关，其中TLR-2在牙周炎中起关键作用。但多数研究报道的TLR-2基因多态性与牙周炎易感性并不一致。因此，我们将所有符合条件的研究纳入我们的研究以进行进一步的荟萃分析。方法. 我们使用了电子数据库，包括 CNKI、PubMed、EMBASE 和 Web of Science 数据库，以及截至 2020 年 6 月发表的相关研究。选择的研究涉及病例对照试验。对于所有资格研究，提供或可以从研究数据计算优势比 (OR) 和 95% 置信区间 (95% CI)。使用 STATA 15.0 计算组合效应的大小。结果。我们的荟萃分析包括 14 篇文章，代表 18 项病例对照研究，共有 3873 例病例和 3438 名对照受试者。在等位基因模型（A等位基因与G等位基因：, , 95% CI: 1.039-1.406), 隐性模型 (GG vs. GA+AA:, , 95% CI: 0.588-0.970), 和共显性模型 (GG VS. AA:, , 95% CI: 0.501-0.925)。在亚组分析中，在等位基因模型下，TLR-2 rs5743708 多态性与亚洲人牙周炎风险相关（G 等位基因与 A 等位基因：, , 95% CI: 1.570-92.688), 主导模型 (GA+AA vs.GG:, , 95% CI: 0.010-0.620), 和共显性模型 (GA VS. GG:, , 95% CI: 0.821-1.282)。结论。TLR-2 rs1898830、rs5743708 多态性可能与牙周炎易感性有关。未来，仍然需要全基因组方法和大规模、多种族的病例对照试验。