Long-term immunological memory mediated by CD4 T cells provides a rapid protection against previously encountered pathogens or antigens. However, it is still controversial how memory CD4 T cells are generated and maintained. Unclear definitions of T-cell memory may be partially responsible for this controversy. It is becoming clear that diverse pathways are responsible for the differentiation and long-term persistence of memory T cells. We herein discuss the diversity of memory cell generation, describing a novel population of resting memory CD4 T cells and their precursors.

中文翻译：

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多种发育途径导致 CD4 T 细胞记忆的产生。

由 CD4 T 细胞介导的长期免疫记忆提供了针对以前遇到的病原体或抗原的快速保护。然而，记忆CD4 T细胞如何产生和维持仍然存在争议。T 细胞记忆的不明确定义可能是造成这一争议的部分原因。越来越清楚的是，记忆 T 细胞的分化和长期持续存在的原因多种多样。我们在此讨论了记忆细胞生成的多样性，描述了一种新的静息记忆 CD4 T 细胞及其前体群体。